Best Western - accommodation in Otay Mesa
More than just hotels
Apartments, cabins, holiday rentals and more, plus millions of reviews from Aussie & Kiwi travellers
Flexibility matters
24/7 support, so you can book with confidence
Unlock member prices with Mates Rates
You could save 10% or more on over 100,000 hotels right now.
Check hotel availability in Otay Mesa
Featured Otay Mesa Best Western accommodation
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2485 Hotel Circle Place San Diego CA
The price is AU$182 per night
AU$182
23 Nov - 24 Nov
includes taxes & fees
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area : Business-friendly hotel with free breakfast and free WiFi. Located in the suburbs.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay
Best Western Seven Seas
411 Hotel Circle South San Diego CA
The price is AU$149 per night
AU$149
15 Dec - 16 Dec
includes taxes & fees
Best Western Seven Seas: Business-friendly hotel with free WiFi and free parking. Located near a metro station.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay
Best Western Chula Vista/Otay Valley Hotel
4450 Main Street, Chula Vista, CA
The price is AU$170 per night
AU$170
23 Nov - 24 Nov
includes taxes & fees
Best Western Chula Vista/Otay Valley Hotel: Business-friendly hotel with free breakfast and free WiFi. Located near the airport.
Pool
Breakfast included
Free cancellation
Reserve now, pay when you stay
Best Western Yacht Harbor Hotel
5005 N Harbor Dr, San Diego, CA
The price is AU$172 per night
AU$172
19 Nov - 20 Nov
includes taxes & fees
Best Western Yacht Harbor Hotel: Business-friendly hotel with free breakfast and free WiFi. Located near whale watching.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay
Best Western Americana Inn
815 W San Ysidro Boulevard, San Ysidro, CA
The price is AU$183 per night
AU$183
23 Nov - 24 Nov
includes taxes & fees
Best Western Americana Inn: Hotel with free breakfast and free WiFi. Located in a shopping district.
Pool
Breakfast included
Free cancellation
Reserve now, pay when you stay
Best Western San Diego Pacific Beach/Mission Bay
2575 Clairemont Dr San Diego CA
The price is AU$127 per night
AU$127
15 Dec - 16 Dec
includes taxes & fees
Best Western San Diego Pacific Beach/Mission Bay: Business-friendly hotel with free WiFi and free parking. Located near theme parks.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay
Best Western Santee Lodge
10726 Woodside Ave, Santee, CA
The price is AU$167 per night
AU$167
23 Nov - 24 Nov
includes taxes & fees
Best Western Santee Lodge: Pet-friendly hotel with free breakfast and free WiFi. Guests love the helpful staff!
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay
Best Western Downtown San Diego
840 A Street, San Diego, CA
The price is AU$236 per night
AU$236
10 Dec - 11 Dec
includes taxes & fees
Best Western Downtown San Diego: Business-friendly hotel with free WiFi and a rooftop terrace. Located near a train station.
Free WiFi
Air conditioning
Free cancellation
Reserve now, pay when you stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Western Accommodation in Otay Mesa
Search for hotels in Otay Mesa on Wotif. You can easily find your hotels in Otay Mesa using one of the methods below:
- View our selection of featured hotels in Otay Mesa
- Use the map to find hotels in the Otay Mesa neighbourhood you prefer
- Use the filters to see hotels in a specific area of Otay Mesa, select a specific theme, brand, or hotel class from basic to luxury hotels in Otay Mesa
- Enter your travel dates to view the best deals on hotels in Otay Mesa - while they last
New reviews! Best hotels in Otay Mesa
Wotif Verified Review
5 / 5
Weekend getaway at this beautiful property was just what i needed defiantly will recommend 10/10
A verified traveller stayed at Legacy Resort Hotel & Spa
Posted 3 hours ago
More Destinations
- Bonita Hotels
- Hyatt Hotels in Temecula
- Marriott Hotels & Resorts in Ladera Ranch
- East Village Hotels
- La Quinta Inn & Suites Hotels in El Cajon
- Hotels near Len Moore Skate Park
- Best Western Hotels in Ocotillo
- Hilton Hotels in Borrego Springs
- Motel 6 Hotels in Spring Valley
- Spring Valley Hotels
- Hyatt Hotels in Dana Point
- South Park Hotels
- Casino Hotels in San Ysidro
- San Ysidro Hotels
- Downtown San Diego Hotels
- Hotels near Coronado Beach
- Best Western Hotels in Julian
- Hotels near Petco Park
- Cabin Rentals in Chula Vista
- Hostels in Chula Vista
- Apartment Hotels in Chula Vista
- Family Hotels in Chula Vista
- Hotels with Hot Tubs in Chula Vista
- Apartment Hotels in San Diego County
- Golf Hotels in San Diego County
- Hotels with a Waterpark in San Diego County
- Winery Hotels in San Diego County
- San Diego County Hotels
- Farmstay in San Diego County
- Cabin Rentals in San Diego County
- Caravan Parks in San Diego County
- Guest Houses in San Diego County
- Hostels in San Diego County
- Hotels near San Diego Convention Center
- La Mesa Hotels
- La Quinta Inn & Suites Hotels in Murrieta
- Motel 6 Hotels in Murrieta
- Wyndham Hotels in Murrieta
- Golden Hill Hotels
- Hyatt Hotels in Escondido
- Hotels with Balconies in Gaslamp Quarter
- Gaslamp Quarter Hotels
- La Quinta Inn & Suites Hotels in Fallbrook
- Accor Hotels in San Clemente
- La Quinta Inn & Suites Hotels in San Clemente
- Casa de Oro-Mount Helix Hotels
- Hilton Hotels in San Juan Capistrano
- Marriott Hotels & Resorts in Wildomar
- Bartell Hotels in San Diego
- Best Western Hotels in San Diego
- Cheap Hotels in San Diego
- Family Hotels in San Diego
- Hotels with Suites in San Diego
- Independent Hotels in San Diego
- Ksl Resorts in San Diego
- La Quinta Inn & Suites Hotels in San Diego
- Loews Hotels in San Diego
- Luxury Hotels in San Diego
- Motel 6 Hotels in San Diego
- Noble House Hotels in San Diego
- Wyndham Hotels in San Diego
- San Diego Hotels
- Houseboats in San Diego
- Hotels near Chula Vista Elite Athlete Training Center
- Four Seasons Hotels in Carlsbad
- Hyatt Hotels in Cardiff-by-the-Sea
- Hotels near The Salvation Army Kroc Center
- Extended Stay America Hotels in Catalina Island
- Hilton Hotels in Catalina Island
- Hyatt Hotels in Catalina Island
- Marriott Hotels & Resorts in Catalina Island
- Hotels near Brown Field Municipal
- Lemon Grove Hotels
- Marriott Hotels & Resorts in Ramona
- Imperial Beach Hotels
- Beach Hotels in Coronado
- Cheap Hotels in Coronado
- Family Hotels in Coronado
- Hotels with Air Conditioning in Coronado
- Hotels with Hot Tubs in Coronado
- Hotels with a Wedding Venue in Coronado
- Coronado Hotels
- National City Hotels
- Hotels near Mount Helix Park
- Wyndham Hotels in Coronado Island
^Eligibility requirements and conditions apply.