Best Western - accommodation in Otay Mesa
More than just hotels
Apartments, cabins, holiday rentals and more, plus millions of reviews from Aussie & Kiwi travellers
Flexibility matters
24/7 support, so you can book with confidence
Unlock member prices with Mates Rates
You could save 10% or more on over 100,000 hotels right now.
Check hotel availability in Otay Mesa
Featured Otay Mesa Best Western accommodation
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2485 Hotel Circle Place, San Diego, CA
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area : Business-friendly hotel with free breakfast and free WiFi. Located near theme parks.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay
Best Western Seven Seas
411 Hotel Circle South, San Diego, CA
Best Western Seven Seas: Business-friendly hotel with free WiFi and free parking. Located near the airport.
Pool
Hot tub
Best Western Chula Vista/Otay Valley Hotel
4450 Main Street, Chula Vista, CA
Best Western Chula Vista/Otay Valley Hotel: Business-friendly hotel with free breakfast and free WiFi. Located near the airport.
Pool
Breakfast included
Free cancellation
Reserve now, pay when you stay
Best Western Yacht Harbor Hotel
5005 N Harbor Dr, San Diego, CA
Best Western Yacht Harbor Hotel: Business-friendly hotel with free breakfast and free WiFi. Located near whale watching.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay
Best Western Americana Inn
815 W San Ysidro Boulevard, San Ysidro, CA
Best Western Americana Inn: Hotel with free breakfast and free WiFi. Located next to the convention centre.
Pool
Breakfast included
Free cancellation
Reserve now, pay when you stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Western Accommodation in Otay Mesa
Search for hotels in Otay Mesa on Wotif. You can easily find your hotels in Otay Mesa using one of the methods below:
- View our selection of featured hotels in Otay Mesa
- Use the map to find hotels in the Otay Mesa neighbourhood you prefer
- Use the filters to see hotels in a specific area of Otay Mesa, select a specific theme, brand, or hotel class from basic to luxury hotels in Otay Mesa
- Enter your travel dates to view the best deals on hotels in Otay Mesa - while they last
New reviews! Best hotels in Otay Mesa
Worth a splurge!
5 / 5
This is a beautiful resort style hotel in downtown San Diego on the water. East walking distance to many shops and restaurants along the water, and also the Midway and Maritime Museums, which we found fascinating. Watch out for the $45/day "destination charge." We did not sample the hotel's several restaurants, except for the "market" with coffee, pastries, yogurt, etc. There is a beautiful pool area behind the hotel great for swimming and sunning. Probably the finest such haven in San Diego. Close to the airport. Enjoyed seeing the aircraft carriers tied up across the bay and the ship traffic so ask for water views, the higher the better.
A verified traveller stayed at Marriott Marquis San Diego Marina
Posted 18 hours ago
Neighbourhoods
Nearby cities
Near an airport
Near an Attraction
Hotel themes
Hotel brands
^Eligibility requirements and conditions apply.