Best Western - accommodation in Otay Mesa
More than just hotels
Apartments, cabins, holiday rentals and more, plus millions of reviews from Aussie & Kiwi travellers
Flexibility matters
24/7 support, so you can book with confidence
Unlock member prices with Mates Rates
You could save 10% or more on over 100,000 hotels right now.
Check hotel availability in Otay Mesa
Featured Otay Mesa Best Western accommodation

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2485 Hotel Circle Place, San Diego, CA
The price is AU$226 per night
AU$226
includes taxes & fees
30 Apr - 1 May
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area : Business-friendly hotel with free breakfast and free WiFi. Located near a metro station.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay

Best Western Seven Seas
411 Hotel Circle South, San Diego, CA
The price is AU$159 per night
AU$159
includes taxes & fees
30 Apr - 1 May
Best Western Seven Seas: Business-friendly hotel with free WiFi and free parking. Located near the airport.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay

Best Western Chula Vista/Otay Valley Hotel
4450 Main Street, Chula Vista, CA
The price is AU$195 per night
AU$195
includes taxes & fees
19 May - 20 May
Best Western Chula Vista/Otay Valley Hotel: Business-friendly hotel with free breakfast and free WiFi. Located near the airport.
Pool
Breakfast included
Free cancellation
Reserve now, pay when you stay

Best Western Yacht Harbor Hotel
5005 N Harbor Dr, San Diego, CA
The price is AU$203 per night
AU$203
includes taxes & fees
30 Apr - 1 May
Best Western Yacht Harbor Hotel: Business-friendly hotel with free breakfast and free WiFi. Located near the airport.
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay

Best Western Americana Inn
815 W San Ysidro Boulevard, San Ysidro, CA
The price is AU$183 per night
AU$183
includes taxes & fees
18 May - 19 May
Best Western Americana Inn: Hotel with free breakfast and free WiFi. Located in the city centre.
Pool
Breakfast included
Free cancellation
Reserve now, pay when you stay

Best Western Santee Lodge
10726 Woodside Ave, Santee, CA
The price is AU$222 per night
AU$222
includes taxes & fees
4 May - 5 May
Best Western Santee Lodge: Pet-friendly hotel with free breakfast and free WiFi. Guests love the helpful staff!
Pool
Hot tub
Free cancellation
Reserve now, pay when you stay

Best Western Downtown San Diego
840 A Street, San Diego, CA
The price is AU$257 per night
AU$257
includes taxes & fees
1 May - 2 May
Best Western Downtown San Diego: Business-friendly hotel with free breakfast and free WiFi. Located near a metro station.
Breakfast included
Free WiFi
Free cancellation
Reserve now, pay when you stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best Western Accommodation in Otay Mesa
Search for hotels in Otay Mesa on Wotif. You can easily find your hotels in Otay Mesa using one of the methods below:
- View our selection of featured hotels in Otay Mesa
- Use the map to find hotels in the Otay Mesa neighbourhood you prefer
- Use the filters to see hotels in a specific area of Otay Mesa, select a specific theme, brand, or hotel class from basic to luxury hotels in Otay Mesa
- Enter your travel dates to view the best deals on hotels in Otay Mesa - while they last
New reviews! Best hotels in Otay Mesa

Wotif Verified Review
5 / 5
I really loved this property and wish I would’ve had more time to spend there. Pool and hot tub was great. My kid loved the ping pong table. The property was beautiful and loved the marina view. They also had nightly movies at the pool for the kiddos.
A verified traveller stayed at The Dana on Mission Bay
Posted 15 hours ago
Neighbourhoods
Nearby cities
Near an airport
Near an Attraction
Hotel themes
Hotel brands
^Eligibility requirements and conditions apply.