American Airlines Flights from Knoxville (TYS) to Melbourne (MLB)

Change your flight without a fee on select flights

Money Saving Bundle when you purchase Hotel + Flight! 

Get mobile alerts about flight delays, gate changes and more with the FREE Wotif app

American Airlines Flights from TYS to MLB

How much is a American Airlines flight from Knoxville (TYS) to Melbourne (MLB)?

One-way flights start as little as and there are roundtrips available from . Get in! You can score some sweet deals with Wotif and American Airlines.

How many non-stop American Airlines flights from Knoxville (TYS) to Melbourne (MLB) are there per day?

American Airlines flies flights direct every day between Knoxville (TYS) and Melbourne (MLB).

How far is Knoxville (TYS) from Melbourne (MLB)?

It’s from Knoxville (TYS) to Melbourne (MLB).

What is the best airline to fly from McGhee Tyson?

At Wotif, we give you all the available options from our reputable partners. Select the airline that best suits your preferences and membership loyalties. You can fly from McGhee Tyson with: . 

Can I change or cancel my American Airlines tickets from Knoxville to Melbourne on Wotif?

Change of plans? No worries! We’re right here to make things as easy as possible. Check out the American Airlines rules and restrictions in your itinerary. You can also use the No Change Fees filter to find flexible plane tickets for future trips. For more information on how to cancel or change your flight on Wotif, visit our customer service portal.

How do I find the best deal on American Airlines flights from Knoxville (TYS) to Melbourne (MLB)?

Just review and compare all our awesome offers or enter your travel dates to see more terrific deals on American Airlines flights from Knoxville. And remember you can save even more when you bundle a hotel with your flight as part of a Wotif package. Sweet!

What’s a good way to get cheap American Airlines flight tickets from Knoxville to Melbourne?

We have loads of cheap flights, so just enter your travel dates to see what’s available. If you can be flexible on when you fly, you’ll find even more epic flight deals. So get booking!

What is the cheapest time of year to fly from Knoxville (TYS) to Melbourne (MLB)?

The cheapest time of the year for a return trip is . One-way, the cheapest month to fly is . Check our deal cards for details.

How long does it take to fly from TYS to MLB?

It typically takes hours to fly directly from Knoxville (TYS) to Melbourne (MLB).

Epic Hotel in Melbourne

Hyatt Place Melbourne Airport

Hyatt Place Melbourne Airport

3 out of 5
747 Air Terminal Pkwy, Melbourne, FL
Loved it!
"Very comfortable room. Nice breakfast of eggs, meat, potatoes, cereal, toast/bagel. Super convenient if you are using the airport but never heard plane noise while there. We will definitely stay again."

Reviewed on 31 Jul. 2025

Hyatt Place Melbourne Airport
Hilton Melbourne, FL

Hilton Melbourne, FL

3.5 out of 5
200 Rialto Place, Melbourne, FL
"Very nice stay, breakfast was amazing definitely worth waking up in time to grab, staff was very nice and affable, there are some chips and paint that need to be fixed on room furniture and on balcony walls, parking is also at a high price per day and the area is not walkable so expect to spend $50+ ..."

Reviewed on 31 Jul. 2025

Hilton Melbourne, FL
Suburban Studios Melbourne Airport

Suburban Studios Melbourne Airport

2 out of 5
1125 Dr. Martin Luther King Jr. Blvd., Melbourne, FL
Older building with nice room renovations
"Within walking distance of MLB airport, I booked 2 nights while visiting the area. The room was very clean with great furnishings, and had a very light "clean" scent. Both the bed and the desk chair were very comfortable, and the bathroom was small but new and functional. My initial impression was ..."

Reviewed on 23 Jul. 2025

Suburban Studios Melbourne Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

^Savings based on all package bookings made with Flight + Hotel on Wotif.com from , as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.