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21C Museum Hotel St Louis

Property class: 4.5

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
Bar (on property)
Exterior
Massages

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet-friendly
  • Free Wi-Fi
  • Air-conditioning
The current price is AU$242
includes taxes & fees
24 May - 25 May

Explore the area

View map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(104 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(33 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed)

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Single Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(2 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed

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About the area

St. Louis

A luxury stay in the heart of St. Louis awaits you at 21C Museum Hotel St Louis . Within just a 10-minute stroll, you'll find popular attractions like St. Louis Union Station and City Museum. Highlights at this hotel include a restaurant, an indoor swimming pool and a bar/lounge. .Enjoy the gym and steam room. Meeting rooms and a business centre are among the business amenities offered. Other amenities include free Wi-Fi in public areas, a coffee shop/cafe and spa services. Cooked-to-order breakfast is available daily between 6:30 AM and 1:00 PM. There's also the convenience of valet parking. .Within a 15-minute walk of this 4.5-property class Downtown West hotel, attractions include Enterprise Center and America's Center Convention Complex.

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.2 km
  • City Museum - 5 min walk - 0.4 km
  • St. Louis Union Station - 8 min walk - 0.7 km
  • Enterprise Center - 8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station - 11 min walk - 1.0 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • Lambert-St. Louis International Airport (STL) - 24 min drive

Restaurants

  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness centre. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business centre and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Conference rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Lift
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and a safe. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries and hairdryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs and telephones. Additionally, rooms include complimentary bottles of water and an iron/ironing board. Change of towels and change of bedsheets can be requested. Housekeeping is provided on a daily basis.

Guests can pamper themselves by indulging in the on-site spa services. Services include massages.

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Downtown St. Louis
  • Pet-friendly
  • Free Wi-Fi
  • Restaurant
  • Air-conditioning
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The price is AU$209
includes taxes & fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 50 per day; includes in/out privileges)
  • Limited on-site valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoke-free property

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
    • Service animals are exempt from fees.

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cots (infant beds) are not available.

Payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business or profession. This property accepts Visa, Mastercard and American Express. Cash is not accepted. For guests' safety, the property includes a fire extinguisher, a smoke detector and outdoor lighting in all accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

What is the cancellation policy at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. Check out the cancellation policy for more info.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of 26 Apr 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on 24 May 2026 start from AU$242, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is parking available at 21C Museum Hotel St Louis ?

Yep, 21C Museum Hotel St Louis has valet parking with in/out privileges for USD 50 per day.

Is there a spa on site at 21C Museum Hotel St Louis ?

There's no onsite spa, but this property does offer services like massages.

Does 21C Museum Hotel St Louis have a pool?

Yep, and guests love it! 21C Museum Hotel St Louis has an indoor pool.

Does 21C Museum Hotel St Louis serve breakfast?

Yeah, cooked-to-order breakfast is offered daily from 6:30 AM to 1:00 PM.

Is there a free airport shuttle available at 21C Museum Hotel St Louis ?

No, 21C Museum Hotel St Louis does not offer an airport shuttle service.

Is there a bar or restaurant at 21C Museum Hotel St Louis ?

Yep, they've got a lounge bar and an onsite restaurant.

What time are check-in & check-out at 21C Museum Hotel St Louis ?

Check-in begins at 4:00 PM. Check-out time is 11:00 AM.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1261 out of 1787 reviews
Rating 8 - Good. 277 out of 1787 reviews
Rating 6 - Okay. 124 out of 1787 reviews
Rating 4 - Poor. 58 out of 1787 reviews
Rating 2 - Terrible. 67 out of 1787 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.4/10

Property conditions & facilities

Reviews

10/10 Excellent

Gwendolyn

Stayed 5 nights in Jan 2026

10/10 Excellent

Stacy

Travelled with family
Liked: Cleanliness, amenities, property conditions & facilities
Staff was great!
Stayed 1 night in Jan 2026

6/10 Okay

Seth

Liked: Cleanliness, staff & service, amenities
I really liked the hotel and the staff were very friendly. The room was clean, but the furnace had an issue and the room did not get warmer than 60 degrees. Beautiful place though and despite the issue we will visit again.
Stayed 1 night in Jan 2026

8/10 Good

Michelle

Liked: Cleanliness, staff & service, amenities
The hotel is nice/convenient to concert/sporting events downtown, and their bar is nice; had a bit of a hiccup trying to access their WiFi which needs addressing, but otherwise the property was very nice!
Stayed 1 night in Jan 2026

10/10 Excellent

ANDREA Nicole

Travelled with family
Liked: Cleanliness, staff & service, amenities
Always a wonderful stay! The staff is top notch and the space is perfect for the imaginative mind! Love love love!
Stayed 2 nights in Oct 2025

10/10 Excellent

Zoey

Stayed 1 night in Jan 2026

10/10 Excellent

NICHOLAS, Nashville

Business traveller
Liked: Cleanliness, amenities, property conditions & facilities
Loved the vibe
Stayed 3 nights in Jan 2026

10/10 Excellent

anthony

Stayed 4 nights in Dec 2025

10/10 Excellent

anthony

Liked: Cleanliness, staff & service, amenities
I love the 21C. It’s filled with character and charm. The staff is always super friendly. I stay here once or twice a month for work, never anything but a wonderful stay.
Stayed 4 nights in Jan 2026

8/10 Good

Kate

Stayed 2 nights in Jan 2026

10/10 Excellent

Mary

Stayed 5 nights in Jan 2026

10/10 Excellent

David

Stayed 1 night in Jan 2026

10/10 Excellent

Samantha

Liked: Cleanliness, staff & service, amenities
Room was clean and staff was very informative. Top tier customer service
Stayed 1 night in Jan 2026

8/10 Good

Kate

Travelled with group
Liked: Cleanliness, amenities, property conditions & facilities
Great staff, cool amenities, amazing environment. We had a lot of fun with the penguins! ;)
Stayed 2 nights in Jan 2026

2/10 Terrible

John

Travelled with family
Liked: Cleanliness, property conditions & facilities, room comfort
Not sure what was up with the 2 who checked us in. The Asian guy was mid ok the black guy who processed everything was your worst employee we’ve had at any location. A front desk guy the next morning, 30’s black man, was beyond great and made up for the guy who did check in. Your bartenders are pretentious hipsters who need to learn basic customer service and how to run a bar efficiently. I’ve been a bartender for over 3 decades. They are jerks. Especially the women with the tattoos. Food was below ave. Paella was jard and al debts. Toast with gambas was charred black, not just in ends. I made a comment about it and got brushed off with a laugh. Valet is atrocious. I’ve never seen valet run like this. They don’t come to you and they don’t do any thing with a sense of urgency as you stand in 20 degree weather. It was odd. There were some great team members. Housekeeping was excellent. Meg, manager at restaurant was incredible. Friendly host stand. Good PM restaurant manager, who was friendly. The gym is incredible. Excellent facility. Too bad check in guy did not mention one word about hours or how to use it. Zero hotel overview. He was definitely not having a good day. I think he was annoyed with my dog who is more well behaved then him. Did not look at my note regarding that she is a certified service animal and the purpose for her requirements to travel with me. Room service was slow and hot food was below Luke warm. The art installation is the best I’ve seen At any 21c
Stayed 1 night in Jan 2026

10/10 Excellent

Dimitre

Travelled with group
Liked: Cleanliness, amenities, property conditions & facilities
Great hotel! Art, food and drinks were fantastic
Stayed 1 night in Jan 2026

6/10 Okay

Jolee

Travelled with group
Will not be staying here again. Room was below expectations for the price and not very clean. Restaurant and room service never answered the phone. Valet service was very kind and timely, gym and sauna were dirty, we stayed two nights and had to go to the lobby to get more toilet paper and clean towels after the calling the front desk for them they told us they didn’t have time.
Stayed 2 nights in Jan 2026

10/10 Excellent

Lawren

Stayed 1 night in Jan 2026

10/10 Excellent

Juanita

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
The rooms were nice and clean. Staff was friendly.
Stayed 1 night in Jan 2026

10/10 Excellent

Lauren

Travelled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jan 2026

8/10 Good

Mikel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great Location, great atmosphere. Drinks and food on the floor level, beautiful artwork is on display.
Stayed 1 night in Jan 2026

10/10 Excellent

Jennifer

Travelled with partner, Travelled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Cool hotel to stay at near enterprise center. Had fun with the penguins and liked the activities in the hotel (museum, pool table, shuffleboard)
Stayed 1 night in Jan 2026

8/10 Good

Sheryl

Travelled with group
Liked: Cleanliness, property conditions & facilities
Front desk staff were abrupt, there was nothing around the hotel
Stayed 8 nights in Jan 2026

10/10 Excellent

Ricky

Liked: Cleanliness, staff & service, amenities
Front desk, SUPER nice man, very informative. Room- spotless, and COMFY bed! Love staying here! Such a unique place to stay! We love it!
Stayed 1 night in Jan 2026

10/10 Excellent

LR

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The cafe that sold breakfast ran out of healthy options each morning (yogurt parfait cup/ overnight oats & quinoa $8 each) They had other plates, egg with meat, etc that looked nice fwiw. Cute gift shop in the cafe. Fashionable hotel with no real 'front desk' just a checkin counter, but volunteers were staffing a St. Louis info table in the lobby while we were there- very friendly. The bar/tapas restaurant across the lobby was fun, $$, and kitchen closed at 10 or so when our events got out so I didn't get to try it. LOVED the historic building, originally a YMCA, the handsome billiards room and the terrific tiled pool with vaulted ceiling- they don't make them like that anymore. Steam room, sauna, showers were great- bring a room towel in case the spa runs short! Open til 10:30p or 11p fyi. Art Museum on the 2nd floor is free to visitors, and had some challenging, gorgeous, funny, and thought-provoking art. Historic Campbell Mansion next door was a neat contrast and a quick peek into the high Victorian era. Glad I went, would stay again
Stayed 3 nights in Jan 2026