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21C Museum Hotel St Louis

Property class: 4.5

Photo gallery for 21C Museum Hotel St Louis

A modern lobby with a large glass sphere, seating areas, and a reception desk.
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
Spa
Bar (on property)
A bar area with high wooden ceilings, a large mural, and a variety of seating options including tables and bar stools.

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet-friendly
  • Free Wi-Fi
  • Air-conditioning
The current price is AU$245
includes taxes & fees
22 Nov - 23 Nov

Explore the area

View map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(140 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

A hotel room with two beds, a large window, a modern ceiling light, and a view of a staircase.

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(44 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

A hotel room with a bunk bed, a round table with a chair, a potted plant, and a colorful abstract painting on the wall.

Room (Bunk Bed)

8.6 out of 10
Excellent
(10 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Single Bunk Bed

View all photos for Loft, 2 Queen Beds

A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

Loft, 2 Queen Beds

7.4 out of 10
Good
(6 reviews)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

A hotel room with a large bed, a desk, a chair, a nightstand, and a mirror.

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

A hotel room with a large bed, a wooden headboard, a nightstand with a lamp, a green armchair, and a large painting on the wall.

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Room

Luxury Suite, 1 King Bed

9.4 out of 10
Exceptional
(3 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

A hotel room with two beds, a sofa, a TV, and a large abstract painting.

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed

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About the area

St. Louis

A luxury stay in the heart of St. Louis awaits you at 21C Museum Hotel St Louis . Within just a 10-minute stroll, you'll find popular attractions like St. Louis Union Station and City Museum. Highlights at this hotel include a restaurant, an indoor swimming pool and a bar/lounge. .Enjoy the gym and steam room. Meeting rooms and a business centre are among the business amenities offered. Other amenities include free Wi-Fi in public areas, a coffee shop/cafe and spa services. Cooked-to-order breakfast is available daily between 6:30 AM and 1:00 PM. There's also the convenience of valet parking. .Within a 15-minute walk of this 4.5-property class Downtown West hotel, attractions include Enterprise Center and America's Center Convention Complex.

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.2 km
  • City Museum - 5 min walk - 0.4 km
  • St. Louis Union Station - 8 min walk - 0.7 km
  • Enterprise Center - 8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station - 11 min walk - 1.0 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • Lambert-St. Louis International Airport (STL) - 24 min drive

Restaurants

  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Hair of the Dog - ‬7 min walk
  • ‪Good Press - ‬1 min walk
  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Medina Grill - ‬5 min walk

About this property

21C Museum Hotel St Louis

21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness centre. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business centre and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Conference rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Lift
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and a safe. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries and hairdryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs and telephones. Additionally, rooms include complimentary bottles of water and an iron/ironing board. Change of towels and change of bedsheets can be requested. Housekeeping is provided on a daily basis.

Guests can pamper themselves by indulging in the on-site spa services. Services include massages.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 55 per day; includes in/out privileges)
  • Limited on-site valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Non-plastic coffee stirrers available
  • Non-plastic drinking straws available
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
    • Service animals are exempt from fees.

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cots (infant beds) are not available.

Payment types

  • American Express
  • Mastercard
  • Visa

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 55 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business or profession. This property accepts Visa, Mastercard and American Express. Cash is not accepted. For guests' safety, the property includes a fire extinguisher, a smoke detector and outdoor lighting in all accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

What is the cancellation policy at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. Check out the cancellation policy for more info.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of 29 Oct 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on 22 Nov 2026 start from AU$245, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is parking available at 21C Museum Hotel St Louis ?

Yep, 21C Museum Hotel St Louis has valet parking with in/out privileges for USD 55 per day.

Is there a spa on site at 21C Museum Hotel St Louis ?

There's no onsite spa, but this property does offer services like massages.

Does 21C Museum Hotel St Louis have a pool?

Yep, and guests love it! 21C Museum Hotel St Louis has an indoor pool.

Does 21C Museum Hotel St Louis serve breakfast?

Yeah, cooked-to-order breakfast is offered daily from 6:30 AM to 1:00 PM.

Is there a free airport shuttle available at 21C Museum Hotel St Louis ?

No, 21C Museum Hotel St Louis does not offer an airport shuttle service.

Is there a bar or restaurant at 21C Museum Hotel St Louis ?

Yep, they've got a lounge bar and an onsite restaurant.

What time are check-in & check-out at 21C Museum Hotel St Louis ?

Check-in begins at 4:00 PM. Check-out time is 11:00 AM.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1511 out of 2148 reviews
Rating 8 - Good. 332 out of 2148 reviews
Rating 6 - Okay. 158 out of 2148 reviews
Rating 4 - Poor. 67 out of 2148 reviews
Rating 2 - Terrible. 80 out of 2148 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.2/10

Property conditions & facilities

Reviews

Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We enjoyed our stay and it’s walking distance to a lot of stuff.
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very clean, nice pool, its a beautiful hotel
Stayed 1 night in Jul 2026
Verified review

8/10 Good

Liked: Cleanliness, staff & service, property conditions & facilities
Disliked: Amenities
Great place
Stayed 2 nights in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Friendly staff Helpful Courteous Great location for downtown activities
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel room was beautiful and very comfortable! The restaurant was amazing, museum was awesome and location was close to everything!
Stayed 1 night in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great stay!
Stayed 3 nights in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We really enjoyed our stay here and would be back for sure! Property is very clean and staff is really hospitable and accommodating.
Stayed 3 nights in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This was a great hotel. They only offer valet parking but it was easy to use.
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
very cool spot and i enjoyed my stay. Nice pool and hottub area too:)
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Have stayed here numerous times. Always my go to for StL
Stayed 2 nights in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice hotel with cool features.
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great interesting hotel. The steam room and sauna and gym are an absolute bonus!
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We Love This Place! Will definitely book here everytime we are in The Lou!
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Definitely ones of the nicest hotels that I have ever stayed at. The hotel and artwork are beautiful. The staff are extremely nice and incredibly professional. Everything about the trip was perfect.
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great stay
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Everything was amazing beautiful hotel and excellent staff
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
clean and nice bar area with outdoor seating area.
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice place great location
Stayed 2 nights in Mar 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Great place to stay.
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The stay was amazing!! Will be staying again!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fabulous experience. The pool and spa were exceptional. Loved every minute.
Stayed 4 nights in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great place and I would stay here again next time in St Louis
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
the hotel was well appointed and staff very attentive.
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice classic clean hotel
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
Great front desk staff! I stayed for Chris Brown & Usher concert.
Stayed 1 night in Jul 2026