Flights from Medellín (MDE) to Santiago (SCL)

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Cheapest Flights from Medellín (MDE) to Santiago (SCL)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
LATAM Airlines Group
LATAM Airlines Group
LATAM Airlines Group
LATAM Airlines Group

Best Day to Book Flight from Medellín (MDE) to Santiago (SCL)

Medellín to Santiago Flight Information

Find the Cheapest Flights from Medellín (MDE) to Santiago (SCL)

Work hard, travel harder! Wotif brings you the cheapest Medellín to Santiago flights, making it possible to have a five star holiday without that five star price tag. Browse and compare our top MDE to SCL routes and airport options. So, go ahead and treat yourself, your sweetheart, or the kids to an unforgettable holiday this year.

to Information

Traveling From
José María Córdova Intl.
Origin Airport
Origin Airport IATA Code
MDE
Traveling To
Arturo Merino Benitez
Destination Airport
Destination Airport IATA Code
SCL
Number of Airlines Serving
Average Flight Time
hours mins
Direct Flight Time
hours mins
Flight Price
AU$683
Address:
Santiago ,
Chile
IATA code:
SCL
Longitude:
-70.793821
Latitude:
-33.397175
Time zone:
America/Santiago
Address:
Medellin ,
Colombia
IATA code:
MDE
Longitude:
-75.428206
Latitude:
6.171382
Time zone:
America/Bogota

Medellín to Santiago Flight Deals from AU$683

Considering a quick trip to Santiago, but not sure which is the best route for you? Well, you’re in luck! Wotif has done the hard work, so all you need to do is check out these flights from MDE to SCL. With heaps of cheap fares from Medellín, we guarantee you’ll be arriving to your holiday destination in style without emptying your bank account in the process.

It’s easy to book flights to Santiago from Medellín  

For a huge choice of flights, simply enter your travel dates and hit search and we’ll hunt out fantastic deals on one-way, return and multi-city airfares to Santiago from Medellín from 10 different airlines. If you click the ‘direct flights’ box, you see flights that’ll get you to Santiago in just hour(s) and mins, too.   

Snap up great deals on flights to Santiago from Medellín 

Choose from flights a day on average, with prices starting at AU$683 and rising to AU$739 depending on the cabin class, travel dates, and airline carrier. And if you’re up for a last-minute getaway, you can get great deals on flights from Medellín to Santiago today!  

Find cheap airfares to Santiago from Medellín 

Here are our insider tips for bagging a flight bargain: 

  • Look for midweek flights and late night, early morning arrival and departure times
  • Check out other airports near Medellín and Santiago
  • Avoid peak season (prices tend to be lower in August)
  • Be flexible with your travel dates and you can usually get cheaper options  

Reasons to book your flights to Santiago from Medellín with Wotif

Wotif is a super-easy way to find the best flight for you to Santiago. Get more bang for your buck on flight and hotel or car rental combos and download the free Wotif app to tap into exclusive deals. Book now with Wotif and have a great flight!

 

Great places to stay after flight from Medellín to Santiago

Holiday Inn Santiago - Airport Terminal by IHG

Holiday Inn Santiago - Airport Terminal by IHG

4 out of 5
Armando Cortinez Norte 2150, Santiago, Region Metropolitana
The price is AU$205 per night from 3 Sept to 4 Sept
AU$205
3 Sept - 4 Sept
Stay at this 4-star ski hotel in Santiago. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in ...
8.8/10 Excellent! (1,344 reviews)
Excellent choice for overnight stay
"Hotel is located between two terminals, domestic one is in front of the hotel, and international 5min walk. It is the most convenient hotel when having early flight from SCL. Hotel itself is old, however it does have a fitness, sauna and swimming pool. They storage your luggage next to the reception ..."

Reviewed on 18 Aug. 2025

Holiday Inn Santiago - Airport Terminal by IHG
City Express by Marriott Santiago Aeropuerto Chile

City Express by Marriott Santiago Aeropuerto Chile

3 out of 5
Av. Américo Vespucio Oriente 1295, Pudahuel, Santiago
The price is AU$132 per night from 5 Sept to 6 Sept
AU$132
5 Sept - 6 Sept
Stay at this 3-star business-friendly hotel in Santiago. Enjoy free breakfast, a free airport shuttle, and 24-hour room service. Our guests praise the breakfast ...
8.6/10 Excellent! (1,005 reviews)
"Great place to stay the night before airport but the airport shuttle can be a bit of a mess with its schedule"

Reviewed on 17 Aug. 2025

City Express by Marriott Santiago Aeropuerto Chile
La Quinta by Wyndham Santiago Aeropuerto

La Quinta by Wyndham Santiago Aeropuerto

4 out of 5
Av. Americo Vespucio 1284, Santiago, Santiago
The price is AU$163 per night from 23 Aug to 24 Aug
AU$163
23 Aug - 24 Aug
Stay at this 4-star spa hotel in Santiago. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the clean rooms in ...
9/10 Wonderful! (1,030 reviews)
"Excellent service"

Reviewed on 16 Aug. 2025

La Quinta by Wyndham Santiago Aeropuerto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

^Savings based on all package bookings made with Flight + Hotel on Wotif.com from , as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.