Flights from Knoxville (TYS) to Panama City (ECP)

Change your flight without a fee on select flights

Money Saving Bundle when you purchase Hotel + Flight! 

Get mobile alerts about flight delays, gate changes and more with the FREE Wotif app


Knoxville to Panama City Flight Information

Find the Cheapest Flights from Knoxville (TYS) to Panama City (ECP)

Work hard, travel harder! Wotif brings you the cheapest Knoxville to Panama City flights, making it possible to have a five star holiday without that five star price tag. Browse and compare our top TYS to ECP routes and airport options. So, go ahead and treat yourself, your sweetheart, or the kids to an unforgettable holiday this year.

to Information

Traveling From
McGhee Tyson
Origin Airport
Origin Airport IATA Code
TYS
Traveling To
Northwest Florida Beaches Intl.
Destination Airport
Destination Airport IATA Code
ECP
Number of Airlines Serving
Average Flight Time
hours mins
Direct Flight Time
hours mins
Flight Price
Address:
Panama City FL,
United States
IATA code:
ECP
Longitude:
-85.798847
Latitude:
30.355819
Time zone:
America/Chicago
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time zone:
America/New_York

Knoxville to Panama City Flight Deals from

Considering a quick trip to Panama City, but not sure which is the best route for you? Well, you’re in luck! Wotif has done the hard work, so all you need to do is check out these flights from TYS to ECP. With heaps of cheap fares from Knoxville, we guarantee you’ll be arriving to your holiday destination in style without emptying your bank account in the process.

It’s easy to book flights to Panama City from Knoxville  

For a huge choice of flights, simply enter your travel dates and hit search and we’ll hunt out fantastic deals on one-way, return and multi-city airfares to Panama City from Knoxville from different airlines. If you click the ‘direct flights’ box, you see flights that’ll get you to Panama City in just hour(s) and mins, too.   

Snap up great deals on flights to Panama City from Knoxville 

Choose from flights a day on average, with prices starting at and rising to depending on the cabin class, travel dates, and airline carrier. And if you’re up for a last-minute getaway, you can get great deals on flights from Knoxville to Panama City today!  

Find cheap airfares to Panama City from Knoxville 

Here are our insider tips for bagging a flight bargain: 

  • Look for midweek flights and late night, early morning arrival and departure times
  • Check out other airports near Knoxville and Panama City
  • Avoid peak season (prices tend to be lower in )
  • Be flexible with your travel dates and you can usually get cheaper options  

Reasons to book your flights to Panama City from Knoxville with Wotif

Wotif is a super-easy way to find the best flight for you to Panama City. Get more bang for your buck on flight and hotel or car rental combos and download the free Wotif app to tap into exclusive deals. Book now with Wotif and have a great flight!

 

Great places to stay after flight from Knoxville to Panama City

TownePlace Suites by Marriott Panama City Beach Pier Park

TownePlace Suites by Marriott Panama City Beach Pier Park

3 out of 5
16000 PANAMA CITY BEACH PARKWAY Panama City Beach FL
The price is AU$116 per night from 4 Feb to 5 Feb
AU$116
4 Feb - 5 Feb
includes taxes & fees
Stay at this business-friendly hotel in Panama City Beach. Enjoy free breakfast, free parking and a 24-hour fitness centre. Our guests praise the breakfast and ...
9.2/10 Wonderful! (1,001 reviews)
Excellent in all areas. Staff, breakfast, bed, amenities... simply done well.

Reviewed on 21 Jan 2026

TownePlace Suites by Marriott Panama City Beach Pier Park
Palmetto Beachfront Hotel, a By the Sea Resort

Palmetto Beachfront Hotel, a By the Sea Resort

2 out of 5
17255 Front Beach Road Panama City Beach FL
Stay at this beach hotel in Panama City Beach. Enjoy free Wi-Fi, free parking and a beach locale. Our guests praise the pool and the helpful staff in their reviews. ...
7.8/10 Good! (2,179 reviews)
I enjoyed my stay. The only issue I had was having to go to my car and smoke. Outside of this, it was PERFECT. Will most definitely be back.

Reviewed on 30 Jan 2026

Palmetto Beachfront Hotel, a By the Sea Resort
Hyatt Place Panama City Beach

Hyatt Place Panama City Beach

3 out of 5
15727 FRONT BEACH ROAD Panama City Beach FL
The price is AU$151 per night from 10 Feb to 11 Feb
AU$151
10 Feb - 11 Feb
includes taxes & fees
Stay at this beach hotel in Panama City Beach. Enjoy free breakfast, free Wi-Fi and a beach locale. Our guests praise the breakfast and the pool in their reviews. ...
9.2/10 Wonderful! (1,615 reviews)
Clean rooms wonderful staff the amenities are great. It’s been my choice the last three years that I’ve been there.

Reviewed on 27 Jan 2026

Hyatt Place Panama City Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More Destinations

^Savings based on all package bookings made with Flight + Hotel on Wotif.com from , as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.