Flights from Knoxville (TYS) to Panama City (ECP)

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Knoxville to Panama City Flight Information

Find the Cheapest Flights from Knoxville (TYS) to Panama City (ECP)

Work hard, travel harder! Wotif brings you the cheapest Knoxville to Panama City flights, making it possible to have a five star holiday without that five star price tag. Browse and compare our top TYS to ECP routes and airport options. So, go ahead and treat yourself, your sweetheart, or the kids to an unforgettable holiday this year.

to Information

Traveling From
McGhee Tyson
Origin Airport
Origin Airport IATA Code
TYS
Traveling To
Northwest Florida Beaches Intl.
Destination Airport
Destination Airport IATA Code
ECP
Number of Airlines Serving
Average Flight Time
hours mins
Direct Flight Time
hours mins
Flight Price
Address:
Panama City FL,
United States
IATA code:
ECP
Longitude:
-85.798847
Latitude:
30.355819
Time zone:
America/Chicago
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time zone:
America/New_York

Knoxville to Panama City Flight Deals from

Considering a quick trip to Panama City, but not sure which is the best route for you? Well, you’re in luck! Wotif has done the hard work, so all you need to do is check out these flights from TYS to ECP. With heaps of cheap fares from Knoxville, we guarantee you’ll be arriving to your holiday destination in style without emptying your bank account in the process.

It’s easy to book flights to Panama City from Knoxville  

For a huge choice of flights, simply enter your travel dates and hit search and we’ll hunt out fantastic deals on one-way, return and multi-city airfares to Panama City from Knoxville from different airlines. If you click the ‘direct flights’ box, you see flights that’ll get you to Panama City in just hour(s) and mins, too.   

Snap up great deals on flights to Panama City from Knoxville 

Choose from flights a day on average, with prices starting at and rising to depending on the cabin class, travel dates, and airline carrier. And if you’re up for a last-minute getaway, you can get great deals on flights from Knoxville to Panama City today!  

Find cheap airfares to Panama City from Knoxville 

Here are our insider tips for bagging a flight bargain: 

  • Look for midweek flights and late night, early morning arrival and departure times
  • Check out other airports near Knoxville and Panama City
  • Avoid peak season (prices tend to be lower in )
  • Be flexible with your travel dates and you can usually get cheaper options  

Reasons to book your flights to Panama City from Knoxville with Wotif

Wotif is a super-easy way to find the best flight for you to Panama City. Get more bang for your buck on flight and hotel or car rental combos and download the free Wotif app to tap into exclusive deals. Book now with Wotif and have a great flight!

 

Great places to stay after flight from Knoxville to Panama City

Hilton Garden Inn Panama City Airport

Hilton Garden Inn Panama City Airport

3 out of 5
5625 Venture Crossings Blvd Panama City FL
The price is AU$166 per night from 1 Jan to 2 Jan
AU$166
1 Jan - 2 Jan 2026
includes taxes & fees
Stay at this business-friendly hotel in Panama City. Enjoy free parking, an outdoor pool and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (672 reviews)
Everything was super clean

Reviewed on 11 Dec 2025

Hilton Garden Inn Panama City Airport
Palmetto Beachfront Hotel, a By the Sea Resort

Palmetto Beachfront Hotel, a By the Sea Resort

2 out of 5
17255 Front Beach Road Panama City Beach FL
Stay at this beach hotel in Panama City Beach. Enjoy free Wi-Fi, free parking and a beach locale. Our guests praise the pool and the helpful staff in their reviews. ...
7.8/10 Good! (2,095 reviews)
When was clean

Reviewed on 15 Dec 2025

Palmetto Beachfront Hotel, a By the Sea Resort
Hampton Inn & Suites Panama City Beach-Beachfront

Hampton Inn & Suites Panama City Beach-Beachfront

2.5 out of 5
15505 Front Beach Road Panama City Beach FL
The price is AU$132 per night from 4 Jan to 5 Jan
AU$132
4 Jan - 5 Jan 2026
includes taxes & fees
Stay at this beach hotel in Panama City Beach. Enjoy free breakfast, free Wi-Fi and a beach locale. Our guests praise the breakfast and the pool in their reviews. ...
8.6/10 Excellent! (2,232 reviews)
Checking was great staff were amazing

Reviewed on 16 Dec 2025

Hampton Inn & Suites Panama City Beach-Beachfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Savings based on all package bookings made with Flight + Hotel on Wotif.com from , as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.